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However, its biological action regarding endometrial stromal cell cytophysiology and function has never been considered. In this study, we investigated the influence of \u03b2\u2010LG on the cellular status of equine endometrial progenitor cells under oxidative stress. The study showed that \u03b2\u2010LG decreased the intracellular accumulation of reactive oxygen species, simultaneously ameliorating cell viability and exerting an anti\u2010apoptotic effect. However, at the transcriptional level, the reduced mRNA expression of pro\u2010apoptotic factors (i.e. BAX and BAD) was accompanied by decreased expression of mRNA for anti\u2010apoptotic BCL\u20102 and genes coding antioxidant enzymes (CAT, SOD\u20101, GPx). Still, we have also noted the positive effect of \u03b2\u2010LG on the expression profile of transcripts involved in endometrial viability and receptivity, including ITGB1, ENPP3, TUNAR and miR\u201019b\u20103p. Finally, the expression of master factors of endometrial decidualization, namely prolactin and IGFBP1, was increased in response to \u03b2\u2010LG, while non\u2010coding RNAs (ncRNAs), that is lncRNA MALAT1 and miR\u2010200b\u20103p, were upregulated. Our findings indicate a novel potential role of \u03b2\u2010LG as a molecule regulating endometrial tissue functionality, promoting viability and normalizing the oxidative status of endometrial progenitor cells. The possible mechanism of \u03b2\u2010LG action includes the activation of ncRNAs essential for tissue regeneration, such as lncRNA MALAT\u20101\/TUNAR and miR\u201019b\u20103p\/miR\u2010200b\u20103p.<\/jats:p>","DOI":"10.1111\/jcmm.17694","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T06:41:48Z","timestamp":1677739308000},"page":"927-938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u03b2\u2010Lactoglobulin affects the oxidative status and viability of equine endometrial progenitor cells via <scp>lncRNA\u2010mRNA\u2010miRNA<\/scp> regulatory associations"],"prefix":"10.1111","volume":"27","author":[{"given":"Krzysztof","family":"Data","sequence":"first","affiliation":[{"name":"Department of Experimental Biology, The Faculty of Biology and Animal Science Wroc\u0142aw University of Environmental and Life Sciences  Wroclaw 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