{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:47:05Z","timestamp":1790858825554,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010857","name":"Jiangxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["20212BAG70034"],"award-info":[{"award-number":["20212BAG70034"]}],"id":[{"id":"10.13039\/501100010857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The transversus thoracis muscle plane (TTMP) block provides effective analgesia in cardiac surgery patients. The aim of this study was to assess whether bilateral TTMP blocks can reduce the incidence of postoperative cognitive dysfunction (POCD) in patients undergoing cardiac valve replacement. A group of 103 patients were randomly divided into the TTM group (<jats:italic>n<\/jats:italic>\u00a0=\u00a052) and the PLA (placebo) group (<jats:italic>n<\/jats:italic>\u00a0=\u00a051). The primary endpoint was the incidence of POCD at 1\u00a0week after surgery. Secondary outcome measures included a reduction of intraoperative mean arterial pressure (MAP) &gt;20% from baseline, intraoperative and postoperative sufentanil consumption, length of stay in the ICU, incidence of postoperative nausea and vomiting (PONV), time to first faeces, postoperative pain at 24\u2009h after surgery, time to extubation and the length of hospital stay. Interleukin (IL)\u20106, TNF\u2010\u03b1, S\u2010100\u03b2, insulin, glucose and insulin resistance were measured at before induction of anaesthesia, 1, 3and 7\u2009days after surgery. The MoCA scores were significantly lower and the incidence of POCD decreased significantly in TTM group compared with PLA group at 7\u2009days after surgery. Perioperative sufentanil consumption, the incidence of PONV and intraoperative MAP reduction &gt;20% from baseline, length of stay in the ICU, postoperative pain at 24\u2009h after surgery, time to extubation and the length of hospital stay were significantly decreased in the TTM group. Postoperatively, IL\u20106, TNF\u2010\u03b1, S\u2010100\u03b2, HOMA\u2010IR, insulin, glucose levels increased and the TTM group had a lower degree than the PLA group at 1, 3 and 7\u2009days after surgery. In summary, bilateral TTMP blocks could improve postoperative cognitive function in patients undergoing cardiac valve replacement.<\/jats:p>","DOI":"10.1111\/jcmm.17710","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T11:39:56Z","timestamp":1678102796000},"page":"976-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of transverse thoracic muscle plane block on postoperative cognitive dysfunction after open cardiac surgery: A randomized clinical trial"],"prefix":"10.1111","volume":"27","author":[{"given":"Shibiao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Nanchang Hongdu Hospital of TCM  Nanchang 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