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The essential trace element selenium plays a pivotal role in the antioxidant and anti\u2010inflammatory defence system of body. This study investigated whether selenium supplementation protected endometrial cells from inflammation in the presence of high\u2010level cortisol. The primary bovine endometrial epithelial cells were subjected to <jats:italic>Escherichia coli<\/jats:italic> lipopolysaccharide to establish cellular inflammation model. The gene expression of inflammatory mediators and proinflammatory cytokines was measured by quantitative PCR. The key proteins of NF\u2010\u03baB and MAPK signalling pathways were detected by Western blot and immunofluorescence. 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These results indicated that selenium has an anti\u2010inflammatory effect, which is mediated via NF\u2010\u03baB and MAPK signalling pathways and is augmented by cortisol in bovine endometrial epithelial cells.<\/jats:p>","DOI":"10.1111\/jcmm.17738","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T06:42:39Z","timestamp":1681281759000},"page":"1373-1383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Selenium suppressed the <scp>LPS<\/scp>\u2010induced inflammation of bovine endometrial epithelial cells through <scp>NF\u2010\u03baB<\/scp> and <scp>MAPK<\/scp> pathways under high cortisol background"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9606-5105","authenticated-orcid":false,"given":"Luying","family":"Cui","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Yangzhou University Jiangsu Co\u2010Innovation 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