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This disease occurs when the immune system, by mistake, generates autoantibodies that target FVIII, causing bleeding. Small RNAs from plasma collected from AH patients (<jats:italic>n<\/jats:italic>\u2009=\u20092), mild classical haemophilia (<jats:italic>n<\/jats:italic>\u2009=\u20093), severe classical haemophilia (<jats:italic>n<\/jats:italic>\u2009=\u20093) and healthy donors (<jats:italic>n<\/jats:italic>\u2009=\u20092), for sequencing by Illumina, NextSeq500. Based on bioinformatic analysis, AH patients were compared to all experimental groups and a significant number of altered transcripts were identified with one transcript being modified compared to all groups at fold change level. The Venn diagram shows that haemoglobin subunit alpha 1 was highlighted to be the common upregulated transcript in AH compared to classical haemophilia and healthy patients. Non\u2010coding RNAs might play a role in AH pathogenesis; however, due to the rarity of HA, the current study needs to be translated on a larger number of AH samples and classical haemophilia samples to generate more solid data that can confirm our findings.<\/jats:p>","DOI":"10.1111\/jcmm.17741","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T04:44:45Z","timestamp":1686804285000},"page":"1790-1796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>RNA<\/scp> sequencing suggests that non\u2010coding <scp>RNAs<\/scp> play a role in the development of acquired haemophilia"],"prefix":"10.1111","volume":"27","author":[{"given":"Adrian Bogdan","family":"Tigu","sequence":"first","affiliation":[{"name":"Medfuture Research Center for Advanced Medicine Iuliu Hatieganu University of Medicine and Pharmacy  Cluj Napoca Romania"},{"name":"Romanian Academy of Scientists  Bucharest 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