{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:51:47Z","timestamp":1784652707432,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013699","name":"Bundesministerium f\u00fcr Bildung, Wissenschaft und Forschung","doi-asserted-by":"publisher","award":["SPA06\/055"],"award-info":[{"award-number":["SPA06\/055"]}],"id":[{"id":"10.13039\/501100013699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013924","name":"Wirtschaftsagentur Wien","doi-asserted-by":"publisher","award":["2343727"],"award-info":[{"award-number":["2343727"]}],"id":[{"id":"10.13039\/501100013924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trauma represents one of the leading causes of death worldwide. Traumatic injuries elicit a dynamic inflammatory response with systemic release of inflammatory cytokines. Disbalance of this response can lead to systemic inflammatory response syndrome or compensatory anti\u2010inflammatory response syndrome. As neutrophils play a major role in innate immune defence and are crucial in the injury\u2010induced immunological response, we aimed to investigate systemic neutrophil\u2010derived immunomodulators in trauma patients. Therefore, serum levels of neutrophil elastase (NE), myeloperoxidase (MPO) and citrullinated histone H3 (CitH3) were quantified in patients with injury severity scores above 15. Additionally, leukocyte, platelet, fibrinogen and CRP levels were assessed. Lastly, we analysed the association of neutrophil\u2010derived factors with clinical severity scoring systems. Although the release of MPO, NE and CitH3 was not predictive of mortality, we found a remarkable increase in MPO and NE in trauma patients as compared with healthy controls. We also found significantly increased levels of MPO and NE on Days 1 and 5 after initial trauma in critically injured patients. Taken together, our data suggest a role for neutrophil activation in trauma. Targeting exacerbated neutrophil activation might represent a new therapeutic option for critically injured patients.<\/jats:p>","DOI":"10.1111\/jcmm.17786","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T04:42:13Z","timestamp":1686976933000},"page":"1859-1866","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Elevation of neutrophil\u2010derived factors in patients after multiple trauma"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0824-8946","authenticated-orcid":false,"given":"Marie\u2010Therese","family":"Lingitz","sequence":"first","affiliation":[{"name":"Division of General Anesthesia and Intensive Care Medicine Department of Anesthesia Critical Care and Pain Medicine Medical University of Vienna  Vienna 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Department of Anesthesia Critical Care and Pain Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas Leopold","family":"Negrin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik jan","family":"Ankersmit","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Medical University of Vienna  Vienna Austria"},{"name":"Laboratory for Cardiac and Thoracic Diagnosis and Regeneration  Vienna 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