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However, its cancer treatment potential needs to be improved by deciphering its corresponding mechanisms of action and optimising therapeutic strategy. In the present study, melatonin inhibited gastric cancer cell migration and soft agar colony formation. Magnetic\u2010activated cell sorting was applied to isolate CD133<jats:sup>+<\/jats:sup> cancer stem cells. Gene expression analysis showed that melatonin lowered the upregulation of LC3\u2010II expression in CD133<jats:sup>+<\/jats:sup> cells compared to CD133<jats:sup>\u2212<\/jats:sup> cells. Several long non\u2010coding RNAs and many components in the canonical Wnt signalling pathway were altered in melatonin\u2010treated cells. In addition, knockdown of long non\u2010coding RNA H19 enhanced the expression of pro\u2010apoptotic genes, Bax and Bak, induced by melatonin treatment. Combinatorial treatment with melatonin and cisplatin was investigated to improve the applicability of melatonin as an anticancer therapy. Combinatorial treatment increased the apoptosis rate and induced G0\/G1 cell cycle arrest. Melatonin can regulate migration and stemness in gastric cancer cells by modifying many signalling pathways. Combinatorial treatment with melatonin and cisplatin has the potential to improve the therapeutic efficacy of both.<\/jats:p>","DOI":"10.1111\/jcmm.17809","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T18:35:11Z","timestamp":1686594911000},"page":"2215-2227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Melatonin regulates cancer migration and stemness and enhances the anti\u2010tumour effect of cisplatin"],"prefix":"10.1111","volume":"27","author":[{"given":"Linglin","family":"Cheng","sequence":"first","affiliation":[{"name":"College of Life and Health Sciences Northeastern University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubo","family":"Li","sequence":"additional","affiliation":[{"name":"Liaoning Center for Animal Disease Control and Prevention Liaoning Agricultural Development Service Center  Shenyang 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