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Extracts from the leaves or fruits of <jats:italic>S. chinensis<\/jats:italic> and their components are used in osteoarthritis (OA). The OA inhibitory effect of schisandrol A, one of its components, has been previously confirmed. We aimed to confirm the OA inhibitory effect of <jats:italic>Schisandra<\/jats:italic> (including components like schisandrol A) to identify why the inhibitory effect of the <jats:italic>Schisandra<\/jats:italic> extract is better. First, we investigated the effects of the <jats:italic>Schisandra<\/jats:italic> extract on OA as a potential therapeutic. Experimental OA was induced in a mouse model via destabilized medial meniscus surgery. The animals were orally administered the <jats:italic>Schisandra<\/jats:italic> extract; the inhibition of cartilage destruction was confirmed using histological analysis. In vitro analysis showed that the <jats:italic>Schisandra<\/jats:italic> extract attenuated osteoarthritic cartilage destruction by regulating IL\u20101\u03b2\u2010induced MMP3 and COX\u20102 levels. The <jats:italic>Schisandra<\/jats:italic> extract inhibited IL\u20101\u03b2\u2010induced degradation of I\u03baB (NF\u2010\u03baB pathway) and IL\u20101\u03b2\u2010induced phosphorylation of p38 and JNK (mitogen\u2010activated protein kinase (MAPK) pathway). RNA\u2010sequencing analysis showed that the <jats:italic>Schisandra<\/jats:italic> extract decreased the expression of IL\u20101\u03b2\u2010induced MAPK and NF\u2010\u03baB signalling pathway\u2010related genes more than schisandrol A alone. Therefore, <jats:italic>Schisandra<\/jats:italic> extract may be more effective than schisandrol A in preventing OA progression by regulating MAPK and NF\u2010\u03baB signalling.<\/jats:p>","DOI":"10.1111\/jcmm.17814","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T07:56:10Z","timestamp":1687247770000},"page":"2071-2081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Schisandra<\/i> extract ameliorates arthritis pathogenesis by suppressing the <scp>NF\u2010\u03baB<\/scp> and <scp>MAPK<\/scp> signalling pathways"],"prefix":"10.1111","volume":"27","author":[{"given":"Seong Jae","family":"Han","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Ajou University Graduate School of Medicine  Suwon Republic of 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