{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:34:08Z","timestamp":1787668448965,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871677"],"award-info":[{"award-number":["81871677"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172295"],"award-info":[{"award-number":["82172295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016806","name":"Natural Science Foundation of Nantong City","doi-asserted-by":"publisher","award":["JC2020021"],"award-info":[{"award-number":["JC2020021"]}],"id":[{"id":"10.13039\/100016806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016806","name":"Natural Science Foundation of Nantong City","doi-asserted-by":"publisher","award":["JCZ20003"],"award-info":[{"award-number":["JCZ20003"]}],"id":[{"id":"10.13039\/100016806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016806","name":"Natural Science Foundation of Nantong City","doi-asserted-by":"publisher","award":["MS22020001"],"award-info":[{"award-number":["MS22020001"]}],"id":[{"id":"10.13039\/100016806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Schistosomiasis is a tropical parasitic disease that damages the liver and poses a serious threat to human health. Macrophages play a key role in the development of liver granulomas and fibrosis by undergoing polarization from M1 to M2 type during schistosomiasis. Therefore, regulating macrophage polarization is important for controlling pathological changes that occur during this disease. Triggering receptor expressed on myeloid cells 2 (TREM2) expressed on the surface of macrophages, dendritic cells and other immune cells has been shown to play a role in inhibiting inflammatory responses and regulating M2 macrophage polarization, however its role in macrophage polarization in schistosomiasis has not been investigated. In this study, we confirmed that TREM2 expression was upregulated in the livers and peritoneal macrophages of mice infected with\n                    <jats:italic>Schistosoma japonicum.<\/jats:italic>\n                    Moreover, the TREM2 expression trend correlated with the expression of M2 macrophage polarization\u2010related molecules in the liver tissues of\n                    <jats:italic>S. japonicum\u2010<\/jats:italic>\n                    infected mice\n                    <jats:italic>.<\/jats:italic>\n                    Using\n                    <jats:italic>Trem2<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, we also showed that\n                    <jats:italic>Trem2<\/jats:italic>\n                    deletion inhibited\n                    <jats:italic>Arg1<\/jats:italic>\n                    and\n                    <jats:italic>Ym1<\/jats:italic>\n                    expression in liver tissues\n                    <jats:italic>. Trem2<\/jats:italic>\n                    deletion also increased the number of F4\/80\u2009+\u2009CD86+ cells in peritoneal macrophages of infected mice\n                    <jats:italic>.<\/jats:italic>\n                    In summary, our study suggests that TREM2 may be involved in M2 macrophage polarization during schistosomiasis.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.17842","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:42:23Z","timestamp":1689036143000},"page":"2261-2269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["<scp>TREM2<\/scp>\n                    expression promotes liver and peritoneal\n                    <scp>M2<\/scp>\n                    macrophage polarization in mice infected with\n                    <i>Schistosoma japonicum<\/i>"],"prefix":"10.1111","volume":"27","author":[{"given":"Dandan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pathogen Biology Medical School of Nantong University  Nantong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology Medical School of Nantong University  Nantong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Affiliated Hospital of Nantong University  Nantong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology Medical School of Nantong University  Nantong People's Republic of 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