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MCL\u2010associated tumour microenvironment (TME) is characterized by M2\u2010like tumour\u2010associated macrophages (TAMs), able to interact with cancer cells, providing tumour survival and resistance to immuno\u2010chemotherapy. Likewise, monocyte\u2010derived nurse\u2010like cells (NLCs) present M2\u2010like profile and provide proliferation signals to chronic lymphocytic leukaemia (CLL), a B\u2010cell malignancy sharing with MCL some biological and phenotypic features. Antibodies against TAMs targeted CD47, a \u2018don't eat me\u2019 signal (DEMs) able to quench phagocytosis by TAMs within TME, with clinical effectiveness when combined with Rituximab in pretreated NHL. Recently, CD24 was found as valid DEMs in solid cancer. Since CD24 is expressed during B\u2010cell differentiation, we investigated and identified consistent CD24 in MCL, CLL and primary human samples. Phagocytosis increased when M2\u2010like macrophages were co\u2010cultured with cancer cells, particularly in the case of paired DEMs blockade (i.e. anti\u2010CD24\u2009+\u2009anti\u2010CD47) combined with Rituximab. Similarly, unstimulated CLL patients\u2010derived NLCs provided increased phagocytosis when DEMs blockade occurred. Since high levels of CD24 were associated with worse survival in both MCL and CLL, anti\u2010CD24\u2010induced phagocytosis could be considered for future clinical use, particularly in association with other agents such as Rituximab.<\/jats:p>","DOI":"10.1111\/jcmm.17868","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T02:09:26Z","timestamp":1693534166000},"page":"3053-3064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of blocking\n                    <scp>CD24<\/scp>\n                    and\n                    <scp>CD47<\/scp>\n                    \u2018don't eat me\u2019 signals in combination with rituximab in mantle\u2010cell lymphoma and chronic lymphocytic leukaemia"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3428-5353","authenticated-orcid":false,"given":"Andrea","family":"Aroldi","sequence":"first","affiliation":[{"name":"Hematology Division San Gerardo Hospital  Monza Italy"},{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-6215","authenticated-orcid":false,"given":"Mario","family":"Mauri","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Ramazzotti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca  Monza 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