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As ET induces angiogenesis and oxygen support, we aimed to verify the effect of exercise on myocardial lipid metabolism disturbance. Wistar rats were divided into Sham, trained Sham (ShamT), AS and trained AS (AST). The exercise consisted of 5\u2010week sessions of treadmill running for 16\u2009weeks. Statistical analysis was conducted by\n                    <jats:sc>anova<\/jats:sc>\n                    or Kruskal\u2013Wallis test and Goodman test. A global correlation between variables was also performed using a two\u2010tailed Pearson's correlation test. AST rats displayed a higher functional capacity and a lower cardiac remodelling and dysfunction when compared to AS, as well as the myocardial capillary rarefaction was prevented. Regarding metabolic properties, immunoblotting and enzymatic assay raised beneficial effects of exercise on fatty acid transport and oxidation pathways. The correlation assessment indicated a positive correlation between variables of angiogenesis and FA utilisation, as well as between metabolism and echocardiographic parameters. In conclusion, early exercise improves exercise tolerance and attenuates cardiac structural and functional remodelling. In parallel, exercise attenuated myocardial capillary and lipid metabolism derangement in rats with aortic stenosis\u2010induced heart failure.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.17908","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T02:08:07Z","timestamp":1693534087000},"page":"2956-2969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of early exercise on cardiac function and lipid metabolism pathway in heart failure"],"prefix":"10.1111","volume":"27","author":[{"given":"S\u00e9rgio Luiz Borges","family":"de Souza","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School S\u00e3o Paulo State University  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Augusto Ferreira","family":"Mota","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, 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