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Exosomal microRNA (miRNA) dysregulation has been shown to be a key player in the pathophysiology of GDM. In this study, we looked into how placental exosomes and their miRNAs may contribute to GDM. When compared to exosomes from healthy pregnant women, it was discovered that miR\u2010135a\u20105p was elevated in placenta\u2010derived exosomes that were isolated from the maternal peripheral plasma of GDM women. Additionally, we discovered that miR\u2010135a\u20105p encouraged HTR\u20108\/SVneo cell growth, invasion and migration. Further research revealed that miR\u2010135a\u20105p activates HTR\u20108\/SVneo cells' proliferation, invasion and migration by promoting PI3K\/AKT pathway activity via Sirtuin 1 (SIRT1). The transfer of exosomal miR\u2010135a\u20105p generated from the placenta could be viewed as a promising agent for targeting genes and pertinent pathways involved in GDM, according to our findings.<\/jats:p>","DOI":"10.1111\/jcmm.17941","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:43:18Z","timestamp":1693892598000},"page":"3729-3743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Placenta\u2010derived exosomal miR\u2010135a\u20105p promotes gestational diabetes mellitus pathogenesis by activating PI3K\/AKT signalling pathway via SIRT1"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4906-3446","authenticated-orcid":false,"given":"Qiuyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital Affiliated Hospital of Fujian Medical University  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