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At the same time, angiogenesis and nerve fibres are more likely to underlie the pathology of pain induced by synovial fibrosis. In the present study, we established a co\u2010culture model of human umbilical vein endothelial cells (HUVECs) with dorsal root ganglion (DRG) and detected tissue and cellular Netrin\u20101, vascular cell adhesion molecule\u20101 (VCAM\u20101), intercellular cell adhesion molecule\u20101 (ICAM\u20101), growth\u2010associated protein\u201043 (GAP43), colorectal cancer deleted (DCC), uncoordinated 5 (UNC5), and the related expression of calcitonin gene\u2010related peptide (CGRP), substance P (SP) and nerve growth factor (NGF) in supernatant by ELISA to investigate the intervention of vascular endothelial cell activation on sensory nerve sprouting exacerbating peripheral pain sensitivity and to investigate the effect of Netrin\u20101 from the perspective of Netrin\u20101 secretion to illustrate its effector mechanism.<\/jats:p>","DOI":"10.1111\/jcmm.17950","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T08:29:12Z","timestamp":1694593752000},"page":"3773-3785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Activation of vascular endothelial cells by synovial fibrosis promotes Netrin\u20101\u2010induced sensory nerve sprouting and exacerbates pain sensitivity"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-4914","authenticated-orcid":false,"given":"Zhenyuan","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine  Nanjing China"},{"name":"Key Laboratory for Metabolic Diseases in Chinese Medicine First College of Clinical Medicine, Nanjing University of Chinese Medicine  Nanjing 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