{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:24:03Z","timestamp":1758122643029,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272059"],"award-info":[{"award-number":["82272059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To develop and validate the predictive effects of stable ferroptosis\u2010 and pyroptosis\u2010related features on the prognosis and immune status of breast cancer (BC). We retrieved as well as downloaded ferroptosis\u2010 and pyroptosis\u2010related genes from the FerrDb and GeneCards databases. The minimum absolute contraction and selection operator (LASSO) algorithm in The Cancer Genome Atlas (TCGA) was used to construct a prognostic classifier combining the above two types of prognostic genes with differential expression, and the Integrated Gene Expression (GEO) dataset was used for validation. Seventeen genes presented a close association with BC prognosis. Thirteen key prognostic genes with prognostic value were considered to construct a new expression signature for classifying patients with BC into high\u2010 and low\u2010risk groups. Kaplan\u2013Meier analysis revealed a worse prognosis in the high\u2010risk group. The receiver operating characteristic (ROC) curve and multivariate Cox regression analysis identified its predictive and independent features. Immune profile analysis showed that immunosuppressive cells were upregulated in the high\u2010risk group, and this risk model was related to immunosuppressive molecules. We successfully constructed combined features of ferroptosis and pyroptosis in BC that are closely related to prognosis, clinicopathological and immune features, chemotherapy efficacy and immunosuppressive molecules. However, further experimental studies are required to verify these findings.<\/jats:p>","DOI":"10.1111\/jcmm.17958","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:34:54Z","timestamp":1697614494000},"page":"3827-3838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development and validation of stable ferroptosis\u2010 and pyroptosis\u2010related signatures in predicting prognosis and immune status in breast cancer"],"prefix":"10.1111","volume":"27","author":[{"given":"Lili","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiology The First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinting","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Hospital of Jilin University  Changchun 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