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There has been no effective prevention or treatment strategy till now. Epithelial\u2010mesenchymal transition (EMT) is a key step in the occurrence and development of RILI. In this study, we demonstrated that emetine dihydrochloride (EDD) alleviated RILI through inhibiting EMT. We found that EDD significantly attenuated EMT\u2010related markers, reduced Smad3 phosphorylation expression after radiation. Then, for the first time, we observed EDD alleviated lung hyperaemia and reduced collagen deposit induced by irradiation, providing protection against RILI. Finally, it was found that EDD inhibited radiation\u2010induced EMT in lung tissues. Our study suggested that EDD alleviated RILI through inhibiting EMT by blocking Smad3 signalling pathways. In summary, our results indicated that EDD is a novel potential radioprotector for RILI.<\/jats:p>","DOI":"10.1111\/jcmm.17959","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T06:05:54Z","timestamp":1695103554000},"page":"3839-3850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Emetine dihydrochloride alleviated radiation\u2010induced lung injury through inhibiting EMT"],"prefix":"10.1111","volume":"27","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Radiobiology (Ministry of Health), School of Public Health Jilin University  Changchun China"},{"name":"Department of Neurology The Third Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery The Second Hospital of Jilin 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