{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:11:26Z","timestamp":1787166686131,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0902400"],"award-info":[{"award-number":["2016YFC0902400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC0909500"],"award-info":[{"award-number":["2017YFC0909500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFSF090207"],"award-info":[{"award-number":["2017YFSF090207"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Co\u2010transplantation of mesenchymal stem cells (MSCs) with telocytes (TCs) was found to have therapeutic effects, although the mechanism of intercellular communication is still unknown. Our current studies aim at exploring the potential molecular mechanisms of TCs interaction and communication with MSCs with a focus on integrin beta1 (ITGB1) in TCs. We found that the co\u2010culture of MSCs with ITGB1\u2010deleted TCs (TC\n                    <jats:sup>\n                      <jats:italic>ITGB1\u2010ko<\/jats:italic>\n                    <\/jats:sup>\n                    ) changed the proliferation, differentiation and growth dynamics ability of MSC in responses to LPS or PI3K inhibitor. Changes of MSC proliferation and apoptosis were accompanied with the dysregulation of cytokine mRNA expression in MSCs co\u2010cultured with TC\n                    <jats:sup>\n                      <jats:italic>ITGB1\u2010ko<\/jats:italic>\n                    <\/jats:sup>\n                    during the exposure of PI3K\u03b1\/\u03b4\/\u03b2 inhibitor, of which IL\u20101\u03b2, IL\u20106 and TNF\u2010\u03b1 increased, while IFN\u2010\u03b3, IL\u20104 and IL\u201010 decreased. The responses of PI3K p85, PI3K p110 and pAKT of MSCs co\u2010cultured with TC\n                    <jats:sup>\n                      <jats:italic>ITGB1\u2010ko<\/jats:italic>\n                    <\/jats:sup>\n                    to LPS or PI3K inhibitor were opposite to those with ITGB1\u2010presented TCs. The intraperitoneal injection of TC\n                    <jats:sup>\n                      <jats:italic>ITGB1\u2010ko<\/jats:italic>\n                    <\/jats:sup>\n                    , TC\n                    <jats:sup>\n                      <jats:italic>vector<\/jats:italic>\n                    <\/jats:sup>\n                    or MSCs alone, as well as the combination of MSCs with TC\n                    <jats:sup>\n                      <jats:italic>ITGB1\u2010ko<\/jats:italic>\n                    <\/jats:sup>\n                    or TC\n                    <jats:sup>\n                      <jats:italic>vector<\/jats:italic>\n                    <\/jats:sup>\n                    exhibited therapeutic effects on LPS\u2010induced acute lung injury. Thus, our data indicate that telocyte ITGB1 contributes to the interaction and intercellular communication between MSCs and TCs, responsible for influencing other cell phenomes and functions.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.17976","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T06:47:27Z","timestamp":1697698047000},"page":"3980-3994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Integrin beta1 mediates the effect of telocytes on mesenchymal stem cell proliferation and migration in the treatment of acute lung injury"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9592-5772","authenticated-orcid":false,"given":"Ruixue","family":"Qi","sequence":"first","affiliation":[{"name":"Jinshan Hospital Center for Tumor Diagnosis &amp; Therapy, Jinshan Hospital Fudan University Shanghai Medical School  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayun","family":"Hou","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute of Clinical Science Fudan University Shanghai Medical School  Shanghai China"},{"name":"Shanghai Engineering Research Center of AI Technology for Cardiopulmonary Diseases  Shanghai China"},{"name":"Shanghai Institute of Clinical Bioinformatics Shanghai Key Laboratory of Lung Inflammation and Injury  Shanghai China"},{"name":"Department of Pulmonary Medicine Shanghai Xuhui Central Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Jinshan Hospital Center for Tumor Diagnosis &amp; Therapy, Jinshan Hospital Fudan University Shanghai Medical School  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Jinshan Hospital Center for Tumor Diagnosis &amp; Therapy, Jinshan Hospital Fudan University Shanghai Medical School  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Wu","sequence":"additional","affiliation":[{"name":"Jinshan Hospital Center for Tumor Diagnosis &amp; Therapy, Jinshan Hospital Fudan University Shanghai Medical School  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiankui","family":"Qiao","sequence":"additional","affiliation":[{"name":"Jinshan Hospital Center for Tumor Diagnosis &amp; Therapy, Jinshan Hospital Fudan University Shanghai Medical School  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8406-7928","authenticated-orcid":false,"given":"Xiangdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinshan Hospital Center for Tumor Diagnosis &amp; Therapy, Jinshan Hospital Fudan University Shanghai Medical School  Shanghai China"},{"name":"Zhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute of Clinical Science Fudan University Shanghai Medical School  Shanghai China"},{"name":"Shanghai Engineering Research Center of AI Technology for Cardiopulmonary Diseases  Shanghai China"},{"name":"Shanghai Institute of Clinical Bioinformatics Shanghai Key Laboratory of Lung Inflammation and Injury  Shanghai China"},{"name":"Department of Pulmonary Medicine Shanghai Xuhui Central Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongli","family":"Song","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute of Clinical Science Fudan University Shanghai Medical School  Shanghai China"},{"name":"Shanghai Engineering Research Center of AI Technology for Cardiopulmonary Diseases  Shanghai China"},{"name":"Shanghai Institute of Clinical Bioinformatics Shanghai Key Laboratory of Lung Inflammation and Injury  Shanghai China"},{"name":"Department of Pulmonary Medicine Shanghai Xuhui Central Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.308"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12149"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-020-0261-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000043R"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.04.037"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2017.05.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmy066"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.248823"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00518.2020"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-016-9328-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-019-09467-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-78771-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.02.008"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1870-y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-019-09487-3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S155279"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1951894"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13199"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.231"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-02168-z"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.17976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T09:32:53Z","timestamp":1705570373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.17976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,19]]},"references-count":20,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/jcmm.17976"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.17976","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,19]]},"assertion":[{"value":"2021-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}