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It has been reported that SAMMSON impacts metabolic regulation, cell proliferation, apoptosis, EMT, drug resistance, invasion and migration. Also, SAMMSON is involved in regulating several pathways such as Wnt, MAPK, PI3K, Akt, ERK and p53. SAMMSON is considered a potential diagnostic and prognostic biomarker in several types of cancer and a suitable therapeutic target. In addition, the highly expressed SAMMSON is closely associated with clinicopathological features of various cancers. SAMMSON has a significant role in regulating epigenetic processes by regulating histone protein or the status of DNA methylation. Herein for the first time, we comprehensively summarized the currently available SAMMSON, molecular regulatory pathways, and clinical significance. We believe that clarifying all the molecular aspects of this lncRNA can be a good guide for cancer studies in the future.<\/jats:p>","DOI":"10.1111\/jcmm.17978","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:55:30Z","timestamp":1695992130000},"page":"3966-3973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The oncogenic role of <scp>SAMMSON lncRNA<\/scp> in tumorigenesis: A comprehensive review with especial focus on melanoma"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-7877","authenticated-orcid":false,"given":"Majid","family":"Ghasemian","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Babaahmadi\u2010Rezaei","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azam","family":"Khedri","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrabose","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202009045"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02633-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120974"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2021.104666"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00447-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113239"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091540"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17161"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-3145"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10111156"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-00833-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190615"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S311499"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-021-02006-x"},{"key":"e_1_2_7_17_1","unstructured":"DewaeleS VanderheydenK De PaepeB et al.Therapeutic Applications of SAMMSON lncRNA Inhibition in Uveal Melanoma.In 2nd International Conference on the Long and the Short of Non\u2010Coding RNAs.2017."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8934210"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01828.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01101-09"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2708"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121829"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-018-0143-4"},{"issue":"6","key":"e_1_2_7_24_1","first-page":"1","article-title":"Overexpression of incrna sammson promotes triple\u2010negative breast cancer cell proliferation by interacting with P53. 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