{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:27:13Z","timestamp":1782289633669,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:00:00Z","timestamp":1703462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013318","name":"ShanXi Science and Technology Department","doi-asserted-by":"publisher","award":["202103021224342"],"award-info":[{"award-number":["202103021224342"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771768"],"award-info":[{"award-number":["81771768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, an increasing number of observational studies have revealed an association between gut microbiota composition and psoriasis patients. However, whether this association reflects a causal relationship remains unclear. This study aimed to identify the causal relationship between gut microbiota and psoriasis through relevant research. In order to determine whether gut microbiota and psoriasis are causally related, we conducted a Mendelian randomization analysis using summary statistics from genome\u2010wide association studies (GWAS). As the exposure factor, we used summary statistics data from a GWAS study conducted by the MiBioGen Consortium, including 18,340 individuals with whole\u2010genome gut microbiota composition, and data from the FinnGen GWAS study on psoriasis, including 9267 patients and 364,071 controls as the disease outcome. Two\u2010sample Mendelian randomization analysis was subsequently performed with inverse variance weighted, MR\u2010Egger and weighted median, while sensitivity analyses were conducted to address heterogeneity and horizontal pleiotropy. The IVW results confirmed the causal relationship between certain gut microbiota groups and psoriasis. Specifically, <jats:italic>family Veillonellaceae<\/jats:italic> (OR\u2009=\u20091.162, 95% CI: 1.038\u20131.301, <jats:italic>p<\/jats:italic>\u2009=\u20090.009), <jats:italic>genus Candidatus Soleaferrea<\/jats:italic> (OR\u2009=\u20091.123, 95% CI: 1.011\u20131.247, <jats:italic>p<\/jats:italic>\u2009=\u20090.030) and <jats:italic>genus Eubacterium fissicatena group<\/jats:italic> (OR\u2009=\u20090.831, 95% CI: 0.755\u20130.915, <jats:italic>p<\/jats:italic>\u2009=\u20090.00016) showed significant associations. Sensitivity analysis did not reveal any abnormalities in SNPs. Currently, we have found some causal relationship between the gut microbiota and psoriasis. However, the study needs further RCTs for further validation.<\/jats:p>","DOI":"10.1111\/jcmm.18023","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T01:06:07Z","timestamp":1703552767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Psoriasis and gut microbiota: A Mendelian randomization study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7849-8255","authenticated-orcid":false,"given":"Ruonan","family":"Wu","sequence":"first","affiliation":[{"name":"School of Public Health Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8842-0074","authenticated-orcid":false,"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanxi Medical University  Taiyuan 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of Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-7167","authenticated-orcid":false,"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Health Statistics and Epidemiology, School of Public Health Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0814-4872","authenticated-orcid":false,"given":"Liyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University  Taiyuan China"},{"name":"Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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