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This study aimed to further investigate the role of <jats:italic>A. muciniphila<\/jats:italic> in SVP\u2010induced hepatotoxicity by orally supplementing rats with the representative strain of <jats:italic>A. muciniphila<\/jats:italic>, <jats:italic>A. muciniphila<\/jats:italic> MucT. Additionally, the fresh faeces were incubated anaerobically with SVP to investigate the effect of SVP on faecal <jats:italic>A. muciniphila<\/jats:italic> in the absence of host influence. Results showed that <jats:italic>A. muciniphila MucT<\/jats:italic> ameliorated the hepatotoxicity and upregulation of <jats:italic>A. muciniphila<\/jats:italic> induced by SVP. SVP also induced a noteworthy elevation of <jats:italic>A. muciniphila<\/jats:italic> level in\u00a0vitro, supporting the observation in\u00a0vivo. Therefore, we speculate that <jats:italic>A. muciniphila<\/jats:italic> MucT may be a potential therapeutic strategy for SVP\u2010induced hepatotoxicity. In addition, the increased <jats:italic>A. muciniphila<\/jats:italic> induced by SVP may differ from <jats:italic>A. muciniphila<\/jats:italic> MucT, but further evidence is needed. These findings provide new insights into the relationships between <jats:italic>A. muciniphila<\/jats:italic> and SVP\u2010induced hepatotoxicity, highlighting the potential for different <jats:italic>A. muciniphila<\/jats:italic> strains to have distinct or even opposing effects on SVP\u2010induced hepatotoxicity.<\/jats:p>","DOI":"10.1111\/jcmm.18026","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T06:14:24Z","timestamp":1699942464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Akkermansia muciniphila<\/i><scp>MucT<\/scp> attenuates sodium valproate\u2010induced hepatotoxicity and upregulation of <i>Akkermansia muciniphila<\/i> in rats"],"prefix":"10.1111","volume":"28","author":[{"given":"Zhi","family":"Cui","sequence":"first","affiliation":[{"name":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou China"},{"name":"Department of Orthopaedics of the 3rd Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4722-3503","authenticated-orcid":false,"given":"Luping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"RahmanM AwosikaAO NguyenH.Valproic Acid. 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