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This study aims to investigate the effect of HNK on angiotensin II (Ang II)\u2010induced myocardial hypertrophy and elucidate the underlying mechanisms. Sprague\u2013Dawley rats were exposed to Ang II infusion, followed by HNK or vehicle treatment for 4\u2009weeks. Our results showed that HNK treatment protected against Ang II\u2010induced myocardial hypertrophy, fibrosis and dysfunction <jats:italic>in vivo<\/jats:italic> and inhibited Ang II\u2010induced hypertrophy in neonatal rat ventricular myocytes <jats:italic>in vitro<\/jats:italic>. Mechanistically, HNK suppressed the Ang II\u2010induced Nur77 expression at the transcriptional level and promoted ubiquitination\u2010mediated degradation of Nur77, leading to dissociation of the Nur77\u2013LKB1 complex. This facilitated the translocation of LKB1 into the cytoplasm and activated the LKB1\u2010AMPK pathway. Our findings suggest that HNK attenuates pathological remodelling and cardiac dysfunction induced by Ang II by promoting dissociation of the Nur77\u2013LKB1 complex and subsequent activation of AMPK signalling. This study uncovers a novel role of HNK on the LKB1\u2010AMPK pathway to protect against cardiac hypertrophy.<\/jats:p>","DOI":"10.1111\/jcmm.18028","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:49:45Z","timestamp":1700588985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Honokiol ameliorates angiotensin <scp>II<\/scp>\u2010induced cardiac hypertrophy by promoting dissociation of the <scp>Nur77\u2013LKB1<\/scp> complex and activating the <scp>AMPK<\/scp> pathway"],"prefix":"10.1111","volume":"28","author":[{"given":"Xiaoyan","family":"Lin","sequence":"first","affiliation":[{"name":"Echocardiological Department, The First Affiliated Hospital Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Fujian Institute of 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