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N6\u2010methyladenosine (m6A), the most common internal modification of eukaryotic mRNA, participates in cancer pathogenesis. In this study, m6A\u2010associated long non\u2010coding RNAs (lncRNA) were retrieved from publicly available databases. Univariate, LASSO, and multivariate Cox regression analyses were performed to establish an m6A\u2010associated lncRNA model specific to DLBCL. Kaplan\u2013Meier curves, principal component analysis, functional enrichment analyses and nomographs were used to study the risk model. The underlying clinicopathological characteristics and drug sensitivity predictions against the model were identified. Risk modelling based on the three m6A\u2010associated lncRNAs was an independent prognostic factor. By regrouping patients using our model\u2010based method, we could differentiate patients more accurately for their response to immunotherapy. In addition, prospective compounds that can target DLBCL subtypes have been identified. The m6A\u2010associated lncRNA risk\u2010scoring model developed herein holds implications for DLBCL prognosis and clinical response prediction to immunotherapy. In addition, we used bioinformatic tools to identify and verify the ceRNA of the m6A\u2010associated lncRNA ELFN1\u2010AS1\/miR\u2010182\u20105p\/BCL\u20102 regulatory axis. ELFN1\u2010AS1 was highly expressed in DLBCL and DLBCL cell lines. ELFN1\u2010AS1 inhibition significantly reduced the proliferation of DLBCL cells and promoted apoptosis. ABT\u2010263 inhibits proliferation and promotes apoptosis in DLBCL cells. In\u00a0vitro and in\u00a0vivo studies have shown that ABT\u2010263 combined with si\u2010ELFN1\u2010AS1 can inhibit DLBCL progression.<\/jats:p>","DOI":"10.1111\/jcmm.18046","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T05:11:45Z","timestamp":1701407505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["m6A\u2010related lncRNAs as potential biomarkers and the lncRNA ELFN1\u2010AS1\/miR\u2010182\u20105p\/BCL\u20102 regulatory axis in diffuse large B\u2010cell lymphoma"],"prefix":"10.1111","volume":"28","author":[{"given":"Qinglong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of General Surgery Guizhou Provincial people's Hospital  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxue","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Guizhou Provincial people's Hospital  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