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To further explore the mechanism behind the involvement of PGC\u20101\u03b1 in AMD pathogenesis we used young (3\u2010month) and old (12\u2010month) mice with knockout in the <jats:italic>PPARGC1A<\/jats:italic> gene and age\u2010matched wild\u2010type (WT) animals. An immunohistochemical analysis showed age\u2010dependent different expression of markers of oxidative stress defence, senescence and autophagy in the retinal pigment epithelium of KO animals as compared with their WT counterparts. Multivariate inference testing showed that senescence and autophagy proteins had the greatest impact on the discrimination between KO and WT 3\u2010month animals, but proteins of antioxidant defence also contributed to that discrimination. A bioinformatic analysis showed that PGC\u20101\u03b1 might coordinate the interplay between genes encoding proteins involved in antioxidant defence, senescence and autophagy in the ageing retina. These data support importance of PGC\u20101\u03b1 in AMD pathogenesis and confirm the utility of mice with PGC\u20101\u03b1 knockout as an animal model to study AMD pathogenesis.<\/jats:p>","DOI":"10.1111\/jcmm.18051","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T05:05:36Z","timestamp":1712207136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>PGC<\/scp>\u20101\u03b1 regulates the interplay between oxidative stress, senescence and autophagy in the ageing retina important in age\u2010related macular degeneration"],"prefix":"10.1111","volume":"28","author":[{"given":"Iswariyaraja Sridevi","family":"Gurubaran","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Eastern Finland  Kuopio 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