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These factors are known to play an important role in osteolysis as well as potential targets for the treatment of osteolysis. Sesamin has been shown to have a variety of biological functions, such as inhibiting inflammation, anti\u2010tumour and involvement in the regulation of fatty acid and cholesterol metabolism. However, the therapeutic effect of sesamin on osteolysis and its mechanism remain unclear. Present studies shown that in the condition of in\u00a0vitro, sesamin could inhibit osteoclastogenesis and bone resorption, as well as suppressing the expression of osteoclast\u2010specific genes. Further studies on the mechanism suggest that the effect of sesamin on human osteoclasts was mediated by blocking the ERK and NF\u2010\u03baB signalling pathways. Besides, sesamin was found to be effective in treating LPS\u2010induced osteolysis by decreasing the production of pro\u2010inflammatory cytokines and inhibiting osteoclastogenesis in\u00a0vivo. Sesamin was non\u2010toxic to heart, liver, kidney, lung and spleen. Therefore, sesamin is a promising phytochemical agent for the therapy of osteolysis\u2010related diseases caused by inflammation and excessive osteoclast activation.<\/jats:p>","DOI":"10.1111\/jcmm.18056","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T19:46:29Z","timestamp":1700682389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sesamin inhibits <scp>RANKL<\/scp>\u2010induced osteoclastogenesis and attenuates <scp>LPS<\/scp>\u2010induced osteolysis via suppression of <scp>ERK<\/scp> and <scp>NF\u2010\u03baB<\/scp> signalling pathways"],"prefix":"10.1111","volume":"28","author":[{"given":"Xiaolong","family":"Yu","sequence":"first","affiliation":[{"name":"Orthopedics Department The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center  Nanchang 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