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Forty male Sprague\u2013Dawley rats were randomly divided into four groups: normoxic control group (C), normoxic resistance training group (R), hypoxic control group (H) and hypoxic resistance training group (HR). Rats in R and HR groups were trained on an incremental weight\u2010bearing ladder every other day, while those in H and HR groups were kept in an environment containing 12.4% O<jats:sub>2<\/jats:sub>. After 4\u2009weeks, muscles were collected for analysis. Differentiated L6 myoblasts were analysed in\u00a0vitro after hypoxia exposure and plasmids transfection (alteration in FoxO1 acetylation). The lean body mass loss, wet weight and fibre cross\u2010sectional area of extensor digitorum longus of rats were decreased after 4\u2009weeks hypoxia, and the adverse reactions above was reversed by resistance training. At the same time, the increase in hypoxia\u2010induced autophagy was suppressed, which was accompanied by a decrease in the expression of nuclear FoxO1 and cytoplasmic Ac\u2010FoxO1 by resistance training. The L6 myotube diameter increased and the expression of autophagic proteins were inhibited under hypoxia via intervening by FoxO1 deacetylation. Overall, resistance training alleviates hypoxia\u2010induced muscle atrophy by inhibiting nuclear FoxO1 and cytoplasmic Ac\u2010FoxO1\u2010mediated autophagy.<\/jats:p>","DOI":"10.1111\/jcmm.18096","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T12:55:51Z","timestamp":1703681751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of resistance training on alleviating hypoxia\u2010induced muscle atrophy: Focus on acetylation of <scp>FoxO1<\/scp>"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6706-375X","authenticated-orcid":false,"given":"Pengyu","family":"Fu","sequence":"first","affiliation":[{"name":"Key Laboratory of Physical Fitness and Exercise, Ministry of Education Beijing Sport University  Beijing China"},{"name":"Department of Physical Education Northwestern Polytechnical University  Xi'an 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