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This study was designed to investigate the protein difference in the aqueous humour and explore new biomarker of the PACG. Aqueous humour (AH) was collected from patients with acute primary angle closure (APAC) and cataract (<jats:italic>n<\/jats:italic>\u2009=\u200910 in APAC group) and patients with cataract only (<jats:italic>n<\/jats:italic>\u2009=\u200910 in control group). Samples were pooled and measured using label\u2010free proteome technology. Then, the differentially expressed proteins (DEPs) were verified by ELISA using independent AH samples (<jats:italic>n<\/jats:italic>\u2009=\u200920 each group). More than 400 proteins were revealed in both groups through proteomics. Comparing the two groups, there were 91DEPs. These proteins participate in biological activities such as inflammation, fibrosis, nerve growth and degeneration and metabolism. We found that the expression of transforming growth factor\u2010\u03b22 and matrilin2 was downregulated in the APAC group. The two proteins are related to inflammation and extracellular matrix formation, which might be involved in angle closure. This study characterized DEPs in AH of the APAC and found a downregulated protein matrilin2.<\/jats:p>","DOI":"10.1111\/jcmm.18111","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T14:21:33Z","timestamp":1705587693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low expression of <scp>TGF<\/scp>\u2010\u03b22 and matrilin2 in human aqueous humour with acute primary angle closure"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-1366","authenticated-orcid":false,"given":"Liming","family":"Wang","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital  Tianjin 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