{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:40:47Z","timestamp":1780472447846,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>UVB radiation can lead to skin photodamage, which might arise from keratinocyte (KC) activation. Nuclear factor kappa B (NF\u2010\u03baB) assumes an essential function in the context of UVB\u2010triggered skin photodamage. Initiating the NF\u2010\u03baB cascade leads to the release of inflammatory factors from KCs. Livin can modulate both KC activation and function, yet it remains uncertain whether and how Livin regulates KC activation induced by UVB. To explore the involvement of Livin in UVB\u2010triggered skin photodamage and its impact on skin damage through NF\u2010\u03baB activation. Immunofluorescence staining was used to analyse the expression of Livin in individuals with skin photodamage and in mice treated with UVB radiation. KC\u2010specific Livin knockout (Livin<jats:sup>\u0394KC<\/jats:sup>) mice and HaCaT cells with Livin knockdown were employed to examine the function of Livin in regulating KC activation induced by UVB radiation. Additionally, the impact of Livin on the NF\u2010\u03baB cascade during KC activation was confirmed via western blot analysis. In patients with skin photodamage, UVB\u2010treated mice and HaCaT cells, Livin expression was reduced in KCs. Livin<jats:sup>\u0394KC<\/jats:sup> mice displayed heightened sensitivity to UVB radiation, resulting in more pronounced skin damage and inflammatory responses compared to the control Livin<jats:sup>fl\/fl<\/jats:sup> mice. Following UVB exposure, both Livin<jats:sup>\u0394KC<\/jats:sup> mice and Livin\u2010knockdown HaCaT cells released elevated levels of cytokines compared to their respective controls. Moreover, the UVB\u2010induced activation of NF\u2010\u03baB in HaCaT cells was significantly enhanced following Livin knockdown. Our findings propose that Livin within KCs could contribute to reducing UVB\u2010induced skin photodamage by regulating the NF\u2010\u03baB pathway.<\/jats:p>","DOI":"10.1111\/jcmm.18124","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T05:31:17Z","timestamp":1707456677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Livin is protective in <scp>UVB<\/scp>\u2010induced skin photodamage by regulating keratinocyte activation and inflammatory responses"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8510-4173","authenticated-orcid":false,"given":"Kaijie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, The 1st affiliated hospital, Jiangxi Medical College Nanchang University  Nanchang 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