{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:13:46Z","timestamp":1787242426941,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The underlying mechanisms mycosis fungoides (MF)\u2010related pruritus remain unclear, and the link between pruritus and systemic inflammation in MF is unexplored. We aimed to investigate systemic inflammation in MF patients and its potential connection to pruritus. In this retrospective study, demographic characteristics, MF stage, clinical and laboratory findings, and neutrophil\u2010lymphocyte ratio (NLR), platelet\u2010lymphocyte ratio (PLR), monocyte\u2010lymphocyte ratio (MLR), systemic immune\u2010inflammation index (SII), systemic inflammation response index (SIRI) and pan\u2010immune inflammation value (PIV) were assessed for all participants. Additionally, mSWAT scores, Dermatology Life Quality Index (DLQI), and pruritus presence and intensity via Visual Analogue Scale (VAS) scoring were recorded for MF patients. A total of 81 patients with early\u2010stage MF and 50 controls were enrolled. Itching was present in 41 patients (50.6%). NLR, PLR, SII, SIRI and CRP values in the MF group were significantly higher. CRP, NLR, mSWAT and DLQI score were significantly higher in MF patients with pruritus than those without. Pruritus was positively correlated with DLQI, mSWAT, CRP, NLR, MLR and SIRI. VAS score was positively correlated with eosinophil count and DLQI. In the multivariate logistic regression model, only NLR was an independent and significant associate of pruritus in patients with MF. This study provides evidence of enhanced systemic inflammation in early\u2010stage MF patients. Additionally, the correlation between pruritus with mSWAT scores and systemic inflammation parameters suggests a potential link between pruritus and the inflammatory milieu in MF.<\/jats:p>","DOI":"10.1111\/jcmm.18125","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:30:02Z","timestamp":1707438602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Systemic inflammation and its relationship with pruritus in early\u2010stage mycosis fungoides"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-2421","authenticated-orcid":false,"given":"Berna","family":"Solak","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia \u00d6zta\u015f","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00851"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15865"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco.2018.10.02"},{"key":"e_1_2_11_5_1","volume-title":"Itch: Mechanisms and Treatment","author":"Misery L","year":"2014"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012057"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.25691"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/15593258211064744"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13081964"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153352"},{"issue":"3","key":"e_1_2_11_11_1","first-page":"140","article-title":"CRP levels as a prognostic factor in mycosis fungoides","volume":"30","author":"Slutsky Bank E","year":"2022","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02391-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13111979"},{"issue":"1","key":"e_1_2_11_14_1","first-page":"25","article-title":"Prognostic evaluation of neutrophil\/lymphocyte ratio in patients with mycosis fungoides","volume":"47","author":"Cengiz FP","year":"2017","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2779-7"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq314"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3845"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06755.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14528"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2019.3560"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.12.021"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.03.003"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.9.1057"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.930979"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.18125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:42:16Z","timestamp":1709167336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.18125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/jcmm.18125"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.18125","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e18125"}}