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The study aimed to evaluate the therapeutic effects of \u03b1\u2010solanine on OA development in a mouse OA model. The OA mice were subjected to varying concentrations of \u03b1\u2010solanine, and various assessments were implemented to assess OA progression. We found that \u03b1\u2010solanine significantly reduced osteophyte formation, subchondral sclerosis and OARSI score. And it decreased proteoglycan loss and calcification in articular cartilage. Specifically, \u03b1\u2010solanine inhibited extracellular matrix degradation by downregulating collagen 10, matrix metalloproteinase 3 and 13, and upregulating collagen 2. Importantly, \u03b1\u2010solanine reversed chondrocyte pyroptosis phenotype in articular cartilage of OA mice by inhibiting the elevated expressions of Caspase\u20101, Gsdmd and IL\u20101\u03b2, while also mitigating aberrant angiogenesis and sensory innervation in subchondral bone. 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