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Neuroinflammation in the spinal cord drives central sensitization and chronic pain. Ferroptosis has potentially important roles in the occurrence of neuroinflammation and chronic pain. In the current study, mouse model of collagen\u2010induced arthritis was established by intradermal injection of type II collagen in complete Freund's adjuvant (CFA) solution. CFA inducement resulted in swollen paw and ankle, mechanical and spontaneous pain, and impaired motor coordination. The spinal inflammation was triggered, astrocytes were activated, and increased NLRP3\u2010mediated inflammatory signal was found in CFA spinal cord. Oxidative stress and ferroptosis in the spinal cord were manifested. Meanwhile, enhancive spinal GSK\u20103\u03b2 activity and abnormal phosphorylated Drp1 were observed. To investigate the potential therapeutic options for arthritic pain, mice were intraperitoneally injected with AB4 for three consecutive days. AB4 treatment reduced pain sensitivity and increased the motor coordination. In the spinal cord, AB4 treatment inhibited NLRP3 inflammasome\u2010mediated inflammatory response, increased antioxidation, decreased mitochondrial reactive oxygen species and ferroptosis. Furthermore, AB4 decreased GSK\u20103\u03b2 activity by binding with GSK\u20103\u03b2 through five electrovalent bonds. Our findings indicated that AB treatment relieves arthritis pain by inhibiting GSK\u20103\u03b2 activation, increasing antioxidant capability, reducing Drp1\u2010mediated mitochondrial dysfunction and suppressing neuroinflammation.<\/jats:p>","DOI":"10.1111\/jcmm.18136","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T06:29:34Z","timestamp":1707460174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Anemoside\n                    <scp>B4<\/scp>\n                    alleviates arthritis pain via suppressing ferroptosis\u2010mediated inflammation"],"prefix":"10.1111","volume":"28","author":[{"given":"Chenlu","family":"Guo","sequence":"first","affiliation":[{"name":"School of Pharmacy Hubei University of Science and Technology  Xianning 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