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GDF11 has also emerged as a critical component in liver development, injury and fibrosis. However, the effects of GDF11 on liver physiology and pathology have been a subject of debate among researchers due to conflicting reported outcomes. While some studies suggest that GDF11 has anti\u2010aging properties, others have documented its senescence\u2010inducing effects. Similarly, while GDF11 has been implicated in exacerbating liver injury, it has also been shown to have the potential to reduce liver fibrosis. In this narrative review, we present a comprehensive report of recent evidence elucidating the diverse roles of GDF11 in liver development, hepatic injury, regeneration and associated diseases such as non\u2010alcoholic fatty liver disease (NAFLD), non\u2010alcoholic steatohepatitis (NASH), liver fibrosis and hepatocellular carcinoma. We also explore the therapeutic potential of GDF11 in managing various liver pathologies.<\/jats:p>","DOI":"10.1111\/jcmm.18140","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T02:49:20Z","timestamp":1710730160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>GDF11<\/scp>: An emerging therapeutic target for liver diseases and fibrosis"],"prefix":"10.1111","volume":"28","author":[{"given":"Pardis","family":"Habibi","sequence":"first","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Transplant Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Falamarzi","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Transplant Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar Dehdari","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Transplant Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Zarei","sequence":"additional","affiliation":[{"name":"Renal Division, Brigham &amp; Women's Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"John B. 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Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-0002","authenticated-orcid":false,"given":"Mahdi","family":"Malekpour","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Transplant Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Azarpira","sequence":"additional","affiliation":[{"name":"Transplant Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,17]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Physiology, liver","author":"Kalra 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