{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:02:52Z","timestamp":1781762572720,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Type 2 diabetes mellitus (T2D) and osteoporosis (OP) are systemic metabolic diseases and often coexist. The mechanism underlying this interrelationship remains unclear. We downloaded microarray data for T2D and OP from the Gene Expression Omnibus (GEO) database. Using weighted gene co\u2010expression network analysis (WGCNA), we identified co\u2010expression modules linked to both T2D and OP. To further investigate the functional implications of these associated genes, we evaluated enrichment using ClueGO software. Additionally, we performed a biological process analysis of the genes unique in T2D and OP. We constructed a comprehensive miRNA\u2013mRNA network by incorporating target genes and overlapping genes from the shared pool. Through the implementation of WGCNA, we successfully identified four modules that propose a plausible model that elucidates the disease pathway based on the associated and distinct gene profiles of T2D and OP. The miRNA\u2013mRNA network analysis revealed co\u2010expression of <jats:italic>PDIA6<\/jats:italic> and <jats:italic>SLC16A1<\/jats:italic>; their expression was upregulated in patients with T2D and islet \u03b2\u2010cell lines. Remarkably, <jats:italic>PDIA6<\/jats:italic> and <jats:italic>SLC16A1<\/jats:italic> were observed to inhibit the proliferation of pancreatic \u03b2 cells and promote apoptosis in\u00a0vitro, while downregulation of <jats:italic>PDIA6<\/jats:italic> and <jats:italic>SLC16A1<\/jats:italic> expression led to enhanced insulin secretion. This is the first study to reveal the significant roles of <jats:italic>PDIA6<\/jats:italic> and <jats:italic>SLC16A1<\/jats:italic> in the pathogenesis of T2D and OP, thereby identifying additional genes that hold potential as indicators or targets for therapy.<\/jats:p>","DOI":"10.1111\/jcmm.18141","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T12:37:21Z","timestamp":1715690241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploration of shared gene signatures and molecular mechanisms between type 2 diabetes and osteoporosis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-0906","authenticated-orcid":false,"given":"Ashuai","family":"Du","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Guizhou Provincial People's Hospital  Guiyang 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