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Differentially expressed genes in ECs were obtained from the Tumour Immune Single\u2010Cell Hub database. Subsequently, a diagnostic signature, a tumour subtyping system and an ECPI were constructed using data from The Cancer Genome Atlas and Gene Expression Omnibus. Associations between the ECPI and the tumour microenvironment, drug sensitivity and biofunctions were assessed. The hub genes in the ECPI were identified as drug candidates by molecular docking. Subtype identification indicated that high EC levels were associated with a worse prognosis and immunosuppressive effect. The diagnostic signature and ECPI were used to effectively diagnose BC and accurately assess the prognosis of BC and drug sensitivity among patients. Three hub genes in the ECPI were extracted, and the three genes had the closest affinity for doxorubicin and curcumin. There was a close relationship between EC and BC. EC\u2010related genes can help clinicians diagnose BC, predict the prognosis of BC and select effective drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcmm.18155","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T05:49:30Z","timestamp":1709358570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Construction of endothelial cell signatures for predicting the diagnosis, prognosis and immunotherapy response of bladder cancer via machine learning"],"prefix":"10.1111","volume":"28","author":[{"given":"Yang","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Urology The First Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The People's Hospital of Liaoning Province  Shenyang Liaoning 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