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However, the specific mechanism of Sema3A in regulation of bone marrow mesenchymal stem cells (BMMSCs) during bone remodelling remains unclear. The tibial denervation model was used and the denervated tibia exhibited significantly lower mass as compared to sham operated bones. In\u00a0vitro, BMMSCs cocultured with dorsal root ganglion cells (DRGs) or stimulated by Sema3A could promote osteogenic differentiation through the Wnt\/\u03b2\u2010catenin\/Nrp1 positive feedback loop, and the enhancement of osteogenic activity could be inhibited by SM345431 (Sema3A\u2010specific inhibitor). In addition, Sema3A\u2010stimulated BMMSCs or intravenous injection of Sema3A could promote new bone formation in\u00a0vivo. To sum up, the coregulation of bone remodelling is due to the ageing of BMMSCs and increased osteoclast activity. Furthermore, the sensory neurotransmitter Sema3A promotes osteogenic differentiation of BMMSCs via Wnt\/\u03b2\u2010catenin\/Nrp1 positive feedback loop, thus promoting osteogenesis in\u00a0vivo and in\u00a0vitro.<\/jats:p>","DOI":"10.1111\/jcmm.18201","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T13:45:05Z","timestamp":1712151905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Peripheral nerve\u2010derived <scp>Sema3A<\/scp> promotes osteogenic differentiation of mesenchymal stem cells through the Wnt\/\u03b2\u2010catenin\/Nrp1 positive feedback loop"],"prefix":"10.1111","volume":"28","author":[{"given":"Jingcun","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery \u2013 Head &amp; Neck Oncology Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology National Clinical Research Center for Oral Diseases; 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