{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:05:47Z","timestamp":1784912747172,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007924","name":"Bengbu Medical College","doi-asserted-by":"publisher","award":["KFZZ202205"],"award-info":[{"award-number":["KFZZ202205"]}],"id":[{"id":"10.13039\/501100007924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatoblastoma (HB), a primary liver tumour, is notorious for its high metastatic potential and poor prognosis. <jats:italic>Ganoderma lucidum<\/jats:italic>, an edible mushroom species utilized in traditional Chinese medicine for addressing various tumour types, presents an intriguing avenue for HB treatment. However, the effectiveness of <jats:italic>G. lucidum<\/jats:italic> in managing HB and its underlying molecular mechanism necessitates further exploration. Standard in\u00a0vitro assays were conducted to evaluate the impact of sporoderm\u2010broken spores of <jats:italic>G. lucidum<\/jats:italic> (SBSGL) on the malignant characteristics of HB cells. The mechanism of SBSGL in treating HB and its tumour immunomodulatory effects were explored and validated by various experiments, including immunoprecipitation, Western blotting, mRFP\u2010GFP\u2010LC3 adenovirus transfection and co\u2010localization analysis, as well as verified with in\u00a0vivo experiments in this regard. The results showed that SBSGL effectively inhibited the malignant traits of HB cells and suppressed the O\u2010GlcNAcylation of RACK1, thereby reducing its expression. In addition, SBSGL inhibited immune checkpoints and regulated cytokines. In conclusion, SBSGL had immunomodulatory effects and regulated the malignancy and autophagy of HB by regulating the O\u2010GlcNAcylation of RACK1. These findings suggest that SBSGL holds promise as a potential anticancer drug for HB treatment.<\/jats:p>","DOI":"10.1111\/jcmm.18223","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T13:34:26Z","timestamp":1709818466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sporoderm\u2010broken spores of <i>Ganoderma lucidum<\/i> modulate hepatoblastoma malignancy by regulating <scp>RACK1<\/scp>\u2010mediated autophagy and tumour immunity"],"prefix":"10.1111","volume":"28","author":[{"given":"Rui","family":"Shen","sequence":"first","affiliation":[{"name":"Graduate School Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ge","sequence":"additional","affiliation":[{"name":"Graduate School Anhui University of Chinese Medicine  Hefei 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