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Catalpol (CA), the primary active component of Rehmanniae Radix, could exert protective effects against various diseases. However, the impact of CA on the treatment of articular cartilage injuries is still unclear. In this study, full\u2010thickness articular cartilage defect was induced in a mouse model via surgery. The animals were intraperitoneally injected with CA for 4 or 8\u2009weeks. According to the results of macroscopic observation, micro\u2010computed tomography CT (\u03bcCT), histological and immunohistochemistry staining, CA treatment could promote mouse cartilage repair, resulting in cartilage regeneration, bone structure improvement and matrix anabolism. Specifically, an increase in the expression of CD90, the marker of mesenchymal stem cells (MSCs), in the cartilage was observed. In addition, we evaluated the migratory and chondrogenic effects of CA on MSCs. Different concentration of CA was added to C3H10 T1\/2 cells. The results showed that CA enhanced cell migration and chondrogenesis without affecting proliferation. Collectively, our findings indicate that CA may be effective for the treatment of cartilage defects via stimulation of endogenous MSCs.<\/jats:p>","DOI":"10.1111\/jcmm.18242","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T02:45:07Z","timestamp":1710989107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Catalpol promotes articular cartilage repair by enhancing the recruitment of endogenous mesenchymal stem cells"],"prefix":"10.1111","volume":"28","author":[{"given":"Congzi","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Orthopaedics and Traumatology of Zhejiang Province The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou Zhejiang China"},{"name":"The First College of Clinical Medicine Zhejiang Chinese Medical University  Hangzhou 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