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The function of intervertebral disc (IVD) mainly depends on the cartilage endplate (CEP), which provides support and waste removal. Therefore, IDD stems from the degeneration of CEP. Our study shows that the expression of lactotransferrin (LTF), an iron\u2010binding protein, is significantly decreased in degenerated human and rat CEP tissues. In addition, we found that LTF knockdown promoted calcification, senescence, and extracellular matrix (ECM) degradation in human endplate chondrocytes. Furthermore, the in\u00a0vivo experiment results confirmed that the JAK2\/STAT3 pathway inhibitor AG490 significantly reversed these effects. In addition to investigating the role and mechanism of LTF in CEP degeneration, this study provides a theoretical basis and experimental evidence to improve IDD treatment.<\/jats:p>","DOI":"10.1111\/jcmm.18267","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T10:05:17Z","timestamp":1728641117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2\/STAT3 pathway"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-5952","authenticated-orcid":false,"given":"Tao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedics The Second Affiliated Hospital of Nanchang University  Nanchang 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