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The tumourigenic potential of this pathway is largely attributed to the activity of YAP\/TAZ, which activate the TEAD1\u20104 transcription factors, leading to the expression of genes involved in cell proliferation and suppression of cell death. Aberrant regulation of the YAP\/TAZ\u2010TEAD signalling axis is commonly observed in malignant pleural mesothelioma (MPM), an insidious neoplasm of the pleural tissue that lines the chest cavity and covers the lungs with poor prognosis. Given the limited effectiveness of current treatments, targeting the YAP\/TAZ\u2010TEAD signalling cascade has emerged as a promising therapeutic strategy in MPM. Several inhibitors of the YAP\/TAZ\u2010TEAD signalling axis are presently undergoing clinical development, with the goal of advancing them to clinical use in the near future.<\/jats:p>","DOI":"10.1111\/jcmm.18330","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T07:15:13Z","timestamp":1712906113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["YAP\/TAZ\u2010TEAD signalling axis: A new therapeutic target in malignant pleural mesothelioma"],"prefix":"10.1111","volume":"28","author":[{"given":"Kostas A.","family":"Papavassiliou","sequence":"first","affiliation":[{"name":"First University Department of Respiratory Medicine, \u2018Sotiria\u2019 Hospital, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia 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