{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:45:32Z","timestamp":1781523932424,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chemotherapy resistance remains a significant challenge in treating ovarian cancer effectively. This study addresses this issue by utilizing a dual drug\u2010loaded nanomicelle system comprising albendazole (ABZ) and paclitaxel (PTX), encapsulated in a novel carrier matrix of D\u2010tocopheryl polyethylene glycol 1000 succinate vitamin E (TPGS), soluplus and folic acid. Our objective was to develop and optimize this nanoparticulate delivery system using solvent evaporation techniques to enhance the therapeutic efficacy against ovarian cancer. The formulation process involved pre\u2010formulation, formulation, optimization, and comprehensive characterization of the micelles. Optimization was conducted through a 32 factorial design, focusing on the effects of polymer ratios on particle size, zeta potential, polydispersity index (PDI) and entrapment efficiency (%EE). The optimal formulation demonstrated improved dilution stability, as indicated by a critical micelle concentration (CMC) of 0.0015\u2009mg\/mL for the TPGS\u2010folic acid conjugate (TPGS\u2010FOL). Extensive characterization included differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and Fourier\u2010transform infrared spectroscopy (FTIR). The release profile exhibited an initial burst followed by sustained release over 90\u2009h. The cytotoxic potential of the formulated micelles was superior to that of the drugs alone, as assessed by MTT assays on SKOV3 ovarian cell lines. Additionally, in\u00a0vivo studies confirmed the presence of both drugs in plasma and tumour tissues, suggesting effective targeting and penetration. In conclusion, the developed TPGS\u2010Fol\u2010based nanomicelles for co\u2010delivering ABZ and PTX show promising results in overcoming drug resistance, enhancing solubility, sustaining drug release, and improving therapeutic outcomes in ovarian cancer treatment.<\/jats:p>","DOI":"10.1111\/jcmm.18389","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:25:46Z","timestamp":1718198746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dual drug\u2010loaded polymeric mixed micelles for ovarian cancer: Approach to enhanced therapeutic efficacy of albendazole and paclitaxel"],"prefix":"10.1111","volume":"28","author":[{"given":"Nikita Maruti","family":"Gaikwad","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics Modern College of Pharmacy  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin Digambar","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Modern College of Pharmacy  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karimunnisa Sameer","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Modern College of Pharmacy  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somdatta Y.","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Modern College of Pharmacy  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep S.","family":"Pathare","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Afzal","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics SCES's Indira College of Pharmacy \u201cNiramay\u201d  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada H.","family":"Aljarba","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science, Princess Nourah bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5136-6166","authenticated-orcid":false,"given":"Ajoy","family":"Kumer","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Arts and Sciences, IUBAT\u2010International University of Business Agriculture and Technology  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-1994","authenticated-orcid":false,"given":"Bikram","family":"Dhara","sequence":"additional","affiliation":[{"name":"Center for Global Health Research Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences  Chennai India"},{"name":"Department of Health Sciences Novel Global Community Educational Foundation  Hebersham New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00199"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11030465"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4172\/2157-7439.1000164"},{"key":"e_1_2_10_5_1","first-page":"12","article-title":"High\u2010fat breakfast increases bioavailability of albendazole compared to low\u2010fat breakfast: single\u2010dose study in healthy subjects","volume":"12","author":"Ochoa D","year":"2021","journal-title":"Front 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