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Our findings reveal that the THBD<jats:sup>+<\/jats:sup> macrophage subpopulation is closely associated with hypoxia in glioma, exhibiting significantly higher infiltration in tumours compared to non\u2010tumour tissues. Moreover, a high proportion of THBD<jats:sup>+<\/jats:sup> cells correlates with poor prognosis in glioblastoma (GBM) patients. Notably, THBD<jats:sup>+<\/jats:sup> macrophages exhibit hypoxic characteristics and epithelial\u2010mesenchymal transition features. Silencing THBD expression leads to a notable reduction in the proliferation and metastasis of glioma cells. Furthermore, we developed a THBD<jats:sup>+<\/jats:sup> macrophage\u2010related risk signature (THBDMRS) through machine learning techniques. THBDMRS emerges as an independent prognostic factor for GBM patients with a substantial prognostic impact. By comparing THBDMRS with 119 established prognostic features, we demonstrate the superior prognostic performance of THBDMRS. 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