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Autoimmunity driven by Th17 cells has been postulated as a potential factor in CP\/CPPS pathogenesis. Nonetheless, elucidating the precise mechanisms governing Th17 cell recruitment to the prostate, triggering inflammation, remained an urgent inquiry. This study illuminated that CCL20 played a pivotal role in attracting Th17 cells to the prostate, thereby contributing to prostatitis development. Furthermore, it identified prostate stromal cells and immune cells as likely sources of CCL20. Additionally, this research unveiled that IL\u201017A, released by Th17 cells, could stimulate macrophages to produce CCL20 through the NF\u2010\u03baB\/MAPK\/PI3K pathway. 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