{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:23:01Z","timestamp":1789093381737,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2023QH1034"],"award-info":[{"award-number":["2023QH1034"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies have demonstrated a close correlation between MicroRNA and the occurrence of aortic dissection (AD). However, the molecular mechanisms underlying this relationship have not been fully elucidated and further exploration is still required. In this study, we found that miR\u2010485\u20103p was significantly upregulated in human aortic dissection tissues. Meanwhile, we constructed in\u00a0vitro AD models in HAVSMCs, HAECs and HAFs and found that the expression of miR\u2010485\u20103p was increased only in HAVSMCs. Overexpression or knockdown of miR\u2010485\u20103p in HAVSMCs could regulate the expression of inflammatory cytokines IL1\u03b2, IL6, TNF\u2010\u03b1, and NLRP3, as well as the expression of apoptosis\u2010related proteins BAX\/BCL2 and Cleaved caspase3\/Caspase3. In the in\u00a0vivo AD model, we have observed that miR\u2010485\u20103p regulates vascular inflammation and apoptosis, thereby participating in the modulation of AD development in mice. Based on target gene prediction, we have validated that SIRT1 is a downstream target gene of miR\u2010485\u20103p. Furthermore, by administering SIRT1 agonists and inhibitors to mice, we observed that the activation of SIRT1 alleviates vascular inflammation and apoptosis, subsequently reducing the incidence of AD. Additionally, functional reversal experiments revealed that overexpression of SIRT1 in HAVSMCs could reverse the cell inflammation and apoptosis mediated by miR\u2010485\u20103p. Therefore, our research suggests that miR\u2010485\u20103p can aggravate inflammation and apoptosis in vascular smooth muscle cells by suppressing the expression of SIRT1, thereby promoting the progression of aortic dissection.<\/jats:p>","DOI":"10.1111\/jcmm.18454","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T03:40:26Z","timestamp":1721101226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>miR<\/scp>\u2010485\u20103p targets <scp>SIRT1<\/scp> in vascular smooth muscle cells mediating the occurrence of aortic dissection"],"prefix":"10.1111","volume":"28","author":[{"given":"Yuling","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Fujian Medical University Union Hospital  Fuzhou Fujian P. R. 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