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Yet the aetiology for POI is still elusive. FBXW7 (F\u2010box with 7 tandem WD) is one of the important components of the Skp1\u2010Cullin1\u2010F\u2010box (SCF) E3 ubiquitin ligase. FBXW7 can regulate cell growth, survival and pluripotency through mediating ubiquitylation and degradation of target proteins via triggering the ubiquitin\u2010proteasome system, and is associated with tumorigenesis, haematopoiesis and testis development. However, evidence establishing the function of FBXW7 in ovary is still lacking. Here, we showed that FBXW7 protein level was significantly decreased in the ovaries of the cisplatin\u2010induced POI mouse model. We further showed that mice with oocyte\u2010specific deletion of <jats:italic>Fbxw7<\/jats:italic> demonstrated POI, characterized with folliculogenic defects, early depletion of follicle reserve, disordered hormonal secretion, ovarian dysfunction and female infertility. Impaired oocyte\u2010GCs communication, manifested as down\u2010regulation of connexin 37, may contribute to follicular development failure in the <jats:italic>Fbxw7<\/jats:italic>\u2010mutant mice. Furthermore, single\u2010cell RNA sequencing and in\u00a0situ hybridization results indicated an accumulation of <jats:italic>Clu<\/jats:italic> and <jats:italic>Ccl2<\/jats:italic> transcripts, which may alter follicle microenvironment deleterious to oocyte development and accelerate POI. Our results establish the important role of <jats:italic>Fbxw7<\/jats:italic> in folliculogenesis and ovarian function, and might provide valuable information for understanding POI and female infertility.<\/jats:p>","DOI":"10.1111\/jcmm.18487","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T12:32:59Z","timestamp":1718973179000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Deletion of <i>Fbxw7<\/i> in oocytes causes follicle loss and premature ovarian insufficiency in mice"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-3527","authenticated-orcid":false,"given":"Huihui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cell Biology, School of Basic Medical Sciences Southern Medical University  Guangzhou Guangdong P.R. 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