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Therefore, modulation of brain RAS by angiotensin receptor blockers (ARBs) and angiotensin\u2010converting enzyme inhibitors (ACEIs) may be effective in reducing the risk and PD neuropathology. It has been shown that all components including the peptides and enzymes of the RAS are present in the different brain areas. Brain RAS plays a critical role in the regulation of memory and cognitive function, and in the controlling of central blood pressure. However, exaggerated brain RAS is implicated in the pathogenesis of different neurodegenerative diseases including PD. Two well\u2010known pathways of brain RAS are recognized including; the classical pathway which is mainly mediated by AngII\/AT1R has detrimental effects. Conversely, the non\u2010classical pathway which is mostly mediated by ACE2\/Ang1\u20107\/MASR and AngII\/AT2R has beneficial effects against PD neuropathology. Exaggerated brain RAS affects the viability of dopaminergic neurons. However, the fundamental mechanism of brain RAS in PD neuropathology was not fully elucidated. Consequently, the purpose of this review is to disclose the mechanistic role of RAS in in the pathogenesis of PD. In addition, we try to revise how the ACEIs and ARBs can be developed for therapeutics in PD.<\/jats:p>","DOI":"10.1111\/jcmm.18495","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T10:11:59Z","timestamp":1718878319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The potential role of brain renin\u2010angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat?"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1024-6376","authenticated-orcid":false,"given":"Zainah","family":"Al\u2010Qahtani","sequence":"first","affiliation":[{"name":"Neurology Section, Internal Medicine Department, College of Medicine King khaled university  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder M.","family":"Al\u2010kuraishy","sequence":"additional","affiliation":[{"name":"Clinical 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