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Hydrogen is a powerful antioxidant which can activate the antioxidant system. A hypoxia\u2010ischaemia brain damage (HIBD) model was established in 7\u2010day\u2010old SD rats. Rats were treated with different doses of hydrogen\u2010rich water (HRW), and brain pericyte oxidative stress damage, cerebrovascular function and brain tissue damage were assessed. Meanwhile, in\u00a0vitro\u2010cultured pericytes were subjected to oxygen\u2013glucose deprivation and treated with different concentrations of HRW. Oxidative injury was measured and the molecular mechanism of how HRW alleviated oxidative injury of pericytes was also examined. The results showed that HRW significantly attenuated HI\u2010induced oxidative stress in the brain pericytes of neonatal rats, partly through the Nrf2\u2010HO\u20101 pathway, further improving cerebrovascular function and reducing brain injury and dysfunction. Furthermore, HRW is superior to a single\u2010cell death inhibitor for apoptosis, ferroptosis, parthanatos, necroptosis and autophagy and can better inhibit HI\u2010induced pericyte death. The liver and kidney functions of rats were not affected by present used HRW dose. This study elucidates the role and mechanism of hydrogen in treating HIBD from the perspective of pericytes, providing new theoretical evidence and mechanistic references for the clinical application of hydrogen in neonatal HIE.<\/jats:p>","DOI":"10.1111\/jcmm.18505","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T05:28:38Z","timestamp":1720848518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hydrogen alleviates hypoxic\u2013ischaemic brain damage in neonatal rats by inhibiting injury of brain pericytes"],"prefix":"10.1111","volume":"28","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics\/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education)\/NHC Key Laboratory of Chronobiology, West China Second University Hospital Sichuan University  Chengdu 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