{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:06:59Z","timestamp":1788955619879,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral nerve defect are common clinical problem caused by trauma or other diseases, often leading to the loss of sensory and motor function in patients. Autologous nerve transplantation has been the gold standard for repairing peripheral nerve defects, but its clinical application is limited due to insufficient donor tissue. In recent years, the application of tissue engineering methods to synthesize nerve conduits for treating peripheral nerve defect has become a current research focus. This study introduces a novel approach for treating peripheral nerve defects using a tissue\u2010engineered PLCL\/SF\/NGF@TA\u2010PPy\u2010RGD conduit. The conduit was fabricated by combining electrospun PLCL\/SF with an NGF\u2010loaded conductive TA\u2010PPy\u2010RGD gel. The gel, synthesized from RGD\u2010modified tannic acid (TA) and polypyrrole (PPy), provides growth anchor points for nerve cells. In\u00a0vitro results showed that this hybrid conduit could enhance PC12 cell proliferation, migration, and reduce apoptosis under oxidative stress. Furthermore, the conduit activated the PI3K\/AKT signalling pathway in PC12 cells. In a rat model of sciatic nerve defect, the PLCL\/SF\/NGF@TA\u2010PPy\u2010RGD conduit significantly improved motor function, gastrocnemius muscle function, and myelin sheath axon thickness, comparable to autologous nerve transplantation. It also promoted angiogenesis around the nerve defect. This study suggests that PLCL\/SF\/NGF@TA\u2010PPy\u2010RGD conduits provide a conducive environment for nerve regeneration, offering a new strategy for peripheral nerve defect treatment, this study provided theoretical basis and new strategies for the research and treatment of peripheral nerve defect.<\/jats:p>","DOI":"10.1111\/jcmm.18544","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T03:40:09Z","timestamp":1722829209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<scp>PLCL<\/scp>\/<scp>SF<\/scp>\/<scp>NGF<\/scp> nerve conduit loaded with <scp>RGD<\/scp>\u2010<scp>TA<\/scp>\u2010<scp>PPY<\/scp> hydrogel promotes regeneration of sciatic nerve defects in rats through <scp>PI3K<\/scp>\/<scp>AKT<\/scp> signalling pathways"],"prefix":"10.1111","volume":"28","author":[{"given":"Kunyu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedic The 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