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SRY\u2010box transcription factor 11 (Sox11) has been reported to serve as a prognostic marker for various cancers. However, the role and mechanism of Sox11 in OLP\u2010related OSCC are unknown. Our results indicated that Sox11 was highly expressed, and that Sox11 promoter methylation was significantly reduced in OLP\u2010associated OSCC tissues. High Sox11 expression and Sox11 promoter hypomethylation indicate a poor patient prognosis. According to in\u00a0vivo and in\u00a0vitro experiments, the knockdown of Sox11 inhibited proliferation, invasion, and migration while driving its apoptotic death in OSSC cells; Sox11 overexpression exerted the opposite effect as Sox11 knockdown. Mechanistically, knockdown of Sox11 inhibited PI3K\/AKT and glycolysis pathway, and overexpression of Sox11 enhanced the PI3K\/AKT and glycolysis pathways in OSCC cells. In addition, we demonstrated that Sox11 overexpression accelerated the progression of OSCC, at least in part by promoting PI3K\/AKT pathway activation. In conclusion, our data indicated that the DNA hypomethylation\u2010associated upregulation of Sox11 could promote oncogenic transformation via the PI3K\/AKT pathway in OLP\u2010associated OSCC. Therefore, Sox11 might be a reliable biomarker for predicting the progression of precancerous oral tissues.<\/jats:p>","DOI":"10.1111\/jcmm.18556","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:40:50Z","timestamp":1721695250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hypomethylation\u2010associated Sox11 upregulation promotes oncogenesis via the PI3K\/AKT pathway in OLP\u2010associated OSCC"],"prefix":"10.1111","volume":"28","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Stomatology, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu Sichuan China"},{"name":"Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu Sichuan China"},{"name":"Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2053-1074","authenticated-orcid":false,"given":"Li","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu Sichuan China"},{"name":"Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu Sichuan China"},{"name":"Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu Sichuan China"},{"name":"Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu Sichuan China"},{"name":"Department of Stomatology Sichuan Provincial People's Hospital Wenjiang Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9216-9951","authenticated-orcid":false,"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu Sichuan China"},{"name":"Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.48"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082413"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13209"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.01.021"},{"key":"e_1_2_13_7_1","first-page":"445","article-title":"Malignant transformation of oral lichen planus. 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