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However, anticancer doses of the drug cause serious damage to the brain. This study aimed to determine the potential protective effects of tangeretin, which has antioxidant and anti\u2010inflammatory properties, in cisplatin\u2010induced neurotoxicity on BALB\/c mice brains. Male BALB\/c mice were randomized and separated into four groups. Tangeretin was given for 10\u2009days by gavage. CIS was injected as a single dose of 10\u2009mg\/kg intraperitoneally (ip) on the 10th day. Brain tissues, malondialdehyde (MDA), total glutathione (tGSH), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and nitric oxide (NO) levels were measured to determine oxidative damage and myeloperoxidase, tumour necrosis factor\u2010alpha (TNF\u2010\u03b1), interleukin 1 beta (IL\u20101\u03b2), IL\u20106 and IL\u201010 were measured to determine inflammatory activity. In addition, 8\u2010OHdG and caspase\u20103 were analysed by immunofluorescence methods. While CIS administration remarkably elevated reactive oxygen species, MDA, and NO levels in brain tissue compared to the control, tGSH, GPx, SOD and CAT levels were significantly decreased. Also, it has been detected that TNF\u2010\u03b1, IL\u20101\u03b2 and IL\u20106 obtained in CIS\u2010treated groups increased as well as IL\u201010 decreased, thereby elevating the inflammatory response. In addition, 8\u2010OHdG and caspase\u20103 immunoreactivity in neurons increased with CIS administration. Treatment with tangeretin ameliorated the deterioration in oxidant\/antioxidant status, overpowered neuroinflammation and ameliorated neurotoxicity\u2010induced apoptosis. This study shows that tangeretin has beneficial effects on CIS\u2010induced neurodegeneration. Possible mechanisms underlying these beneficial effects include the antioxidant and anti\u2010inflammatory properties of tangeretin.<\/jats:p>","DOI":"10.1111\/jcmm.18565","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T23:26:22Z","timestamp":1721777182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of tangeretin on cisplatin\u2010induced oxido\u2010inflammatory brain damage in rats"],"prefix":"10.1111","volume":"28","author":[{"given":"Betul","family":"Cicek","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Erzincan Binali Yildirim University  Erzincan Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Danisman","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine Ataturk University  Erzurum 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