{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:27Z","timestamp":1787015367615,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    During coronary artery bypass grafting (CABG), the surgical procedure, particularly the manipulation of the major arteries of the heart, induces a significant inflammatory state that may compromise platelet function to the extent that platelet transfusion is required. Given stored platelets as a major source of biological mediators, this study investigates the effects of platelet transfusion on the major pro\u2010aggregatory, pro\u2010inflammatory and immunomodulatory markers of platelets. Platelets from 20 patients, 10 who received platelet transfusion and 10 without, were subjected to flow cytometery where P\u2010selectin and CD40 ligand (CD40L) expressions and PAC\u20101 binding (activation\u2010specific anti GPIIb\/GPIIIa antibody)\u00a0analysed at five\u2010time points of 24 h before surgery, immediately, 2\u2009h, 24\u2009h and 1\u2009week after surgery. Analysis of intra\u2010platelet transforming growth factor\u2010beta\u20101 (TGF\u2010\u03b21) was also conducted using western blotting. Patients with platelet transfusion showed increased levels of P\u2010selectin, CD40L and intra\u2010platelet TGF\u2010\u03b21 2\u2010h after surgery compared to those without transfusion (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). PAC\u20101 binding was increased 24\u2009h after surgery in transfused patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Given the significant post\u2010transfusion elevation of platelet TGF\u2010\u03b21, P\u2010sel\/CD40L reduction in transfused patients a week after was of much interest. This study showed for the first time the significant effects of platelet transfusion on the pro\u2010inflammatory, pro\u2010aggeregatory and immunomodulatory state of platelets in CABG patients, which manifested with immediate, midterm and delayed consequences. While the increased pro\u2010inflammatory conditions manifested as an immediate effect of platelet transfusion, the pro\u2010aggregatory circumstances emerged 24\u00a0h post\u2010transfusion. A week after surgery, attenuations of pro\u2010inflammatory markers of platelets in transfused patients were shown, which might be due to the immunomodulatory effects of TGF\u2010\u03b21.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.18573","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T14:05:01Z","timestamp":1723212301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Platelet transfusion enhances pro\u2010aggregatory status shortly after\u00a0coronary artery bypass grafting (\n                    <scp>CABG<\/scp>\n                    ) while modulating platelet pro\u2010inflammatory state 1\u2010week post\u2010surgery"],"prefix":"10.1111","volume":"28","author":[{"given":"Javad","family":"Ahmadi","sequence":"first","affiliation":[{"name":"Blood Transfusion Research Center High Institute for Research and Education in Transfusion Medicine  Tehran Iran"},{"name":"Torbat Heydariyeh University of Medical Sciences  Torbat Heydariyeh Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehteramolsadat","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Blood Transfusion Research Center High Institute for Research and Education in Transfusion Medicine  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faranak","family":"Kargar","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular Medical and Research Center Iran University of Medical Science  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahtab","family":"Maghsudlu","sequence":"additional","affiliation":[{"name":"Blood Transfusion Research Center High Institute for Research and Education in Transfusion Medicine  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-5649","authenticated-orcid":false,"given":"Mehran","family":"Ghasemzadeh","sequence":"additional","affiliation":[{"name":"Blood Transfusion Research Center High Institute for Research and Education in Transfusion Medicine  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2019-0049"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.1995.tb00663.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezab391"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.05.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.29252\/IJMR-060101"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2018.09.014"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2022.12.009"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01089.x"},{"key":"e_1_2_11_10_1","volume-title":"Overview of Platelet Transfusion. 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