{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:08:07Z","timestamp":1789610887078,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute myeloid leukaemia (AML) remains a major unmet medical, despite recent progress in targeted molecular therapies. One aspect of leukaemic cell resistance to chemotherapy is the development of clones with increased capacity to respond to cellular stress and the production of reactive oxygen species (ROS), thanks in particular to a high aldehyde dehydrogenases (ALDH) 1A1\/2 activity. At diagnosis, ROS level and ALDH1A1\/2 activity in AML patients BM are correlated with the different ELN 2022 prognostic groups and overall survival (OS). A significant lower ALDH1A1\/2 activity in BM was observed in the favourable ELN2022 subgroup compared to the intermediate and adverse group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). In the same way, the ROS levels were significantly lower in the favourable ELN 2022 subgroup compared to the intermediate group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and adverse group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0002). ROS<jats:sup>high<\/jats:sup> AML patients had a significantly lower median overall survival (OS) (8.2\u2009months) than ROS<jats:sup>low<\/jats:sup> patients (24.6\u2009months) (<jats:italic>p<\/jats:italic>\u2009=\u20090.0368). After first\u2010line therapy, a significant increase of ROS level (<jats:italic>p<\/jats:italic>\u2009=\u20090.015) and ALDH1A1\/2 activity (0\u2009=\u20090.0273) in leukaemic blasts was observed, especially in the refractory ones. ABD\u20103001, a competitive and irreversible inhibitor of ALDHs 1 and 3, can in\u00a0vitro inhibit the proliferation of patient\u2010derived leukaemic cells in accordance with redox balance. In multivariate analysis, ROS level was the most significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and the strongest predictive factor for the sensitivity of cells to ABD\u20103001. The safety profile of ABD\u20103001 is currently being assessed through the first inhuman multicenter phase 1 clinical trial \u201cODYSSEY\u201d (NCT05601726) for patients with relapsed AML.<\/jats:p>","DOI":"10.1111\/jcmm.70011","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T10:40:31Z","timestamp":1728643231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Reactive oxygen species and aldehyde dehydrogenase <scp>1A<\/scp> as prognosis and theragnostic biomarker in acute myeloid leukaemia patients"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4479-7480","authenticated-orcid":false,"given":"G.","family":"Venton","sequence":"first","affiliation":[{"name":"APHM, H\u00f4pital de la Conception, Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire  Marseille France"},{"name":"TAGC\u2010Theories and Approaches of Genomic Complexity Aix Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Colle","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital de la Conception, Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire  Marseille France"},{"name":"TAGC\u2010Theories and Approaches of Genomic Complexity Aix Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1114-6385","authenticated-orcid":false,"given":"A.","family":"Tichadou","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital de la Conception, Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire  Marseille France"},{"name":"TAGC\u2010Theories and Approaches of Genomic Complexity Aix Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Quessada","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital La Timone, 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