{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:27:39Z","timestamp":1794029259555,"version":"4.8.0"},"reference-count":53,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012286","name":"Deputy for Research and Technology, Kermanshah University of Medical Sciences","doi-asserted-by":"publisher","award":["4020751"],"award-info":[{"award-number":["4020751"]}],"id":[{"id":"10.13039\/501100012286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic inflammation is believed as the main culprit of the link between cardiovascular disease (CVD) and rheumatoid arthritis (RA). Interleukin\u20106 (IL\u20106) is a pro\u2010inflammatory cytokine with a key role in RA pathophysiology and also correlates with joint destruction and disease activity. This study evaluates the association between IL\u20106 plasma level and cardiac biomarker NT\u2010proBNP, HS\u2010CRP, CVD predictor algorithms, Framingham Risk Score (FRS) and Systematic Coronary Risk Evaluation (SCORE), as well as with CXCL9 and its receptor, CXCR3 in RA patients compared to the controls. Sixty RA patients (30 early and 30 late) and 30 healthy persons were included in this study. IL\u20106 and NT\u2010proBNP plasma levels were measured by the ELISA. Also, HS\u2010CRP plasma levels were quantified using the immunoturbidimetric assay. The CVD risk was assessed by the FRS and SCORE. IL\u20106 plasma levels were significantly higher in the early and late RA patients compared to the controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was a positive correlation between IL\u20106 with DAS\u201028 (<jats:italic>p<\/jats:italic>\u2009=\u20090.007, <jats:italic>r<\/jats:italic>\u2009=\u20090.346), BPS (<jats:italic>p<\/jats:italic>\u2009=\u20090.002, <jats:italic>r<\/jats:italic>\u2009=\u20090.396), BPD (<jats:italic>p<\/jats:italic>\u2009=\u20090.046, <jats:italic>r<\/jats:italic>\u2009=\u20090.259), SCORE (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>r<\/jats:italic>\u2009=\u20090.472), and FRS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>r<\/jats:italic>\u2009=\u20090.553), and a negative association with HDL (<jats:italic>p<\/jats:italic>\u2009=\u20090.037, <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.270), in the patients. Also, IL\u20106 plasma level positively correlated with HS\u2010CRP (<jats:italic>p<\/jats:italic>\u2009=\u20090.021, <jats:italic>r<\/jats:italic>\u2009=\u20090.297) and NT\u2010proBNP (<jats:italic>p<\/jats:italic>\u2009=\u20090.045, <jats:italic>r<\/jats:italic>\u2009=\u20090.260) in the patients. Furthermore, a positive association was found between IL\u20106 plasma levels and CXCL9 (<jats:italic>p<\/jats:italic>\u2009=\u20090.002, <jats:italic>r<\/jats:italic>\u2009=\u20090.386), and CXCR3 (<jats:italic>p<\/jats:italic>\u2009=\u20090.018, <jats:italic>r<\/jats:italic>\u2009=\u20090.304) in the patients. Given the interesting association between IL\u20106 with various variables of CVD, IL\u20106 may be considered a biomarker for assessing the risk for future cardiovascular events in RA patients.<\/jats:p>","DOI":"10.1111\/jcmm.70028","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T03:19:30Z","timestamp":1724123970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Interleukin\u20106 positively correlates with cardiovascular disease predictor algorithms and biomarker in rheumatoid arthritis patients"],"prefix":"10.1111","volume":"28","author":[{"given":"Seyed Askar","family":"Roghani","sequence":"first","affiliation":[{"name":"Immunology Department, Faculty of Medicine Kermanshah University of Medical Sciences  Kermanshah Iran"},{"name":"Clinical Research Development Center, Imam Reza Hospital Kermanshah University of Medical Sciences  Kermanshah Iran"},{"name":"Medical 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