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Although the general symptoms have been known for a long time, new treatment possibilities, the detection of different biomarkers, and innovations in diagnosis and follow\u2010up have paved the way for further studies. Recent studies have shown that the immune system has become an essential factor associated with disease progression. The role of Gaucher cells in the disease is well characterized. In addition to phagocytic macrophage cells, lymphocytes, complement system, and inflammatory pathway elements are also implicated in GD as they were shown to be the underlying factors causing associated pathologies such as Parkinson's. In this article, the relationship between the GD and the immune system has been examined and reviewed in light of new findings.<\/jats:p>","DOI":"10.1111\/jcmm.70087","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T06:39:43Z","timestamp":1730097583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Old disease\u2014New reflections: Gaucher, immunity, and inflammation"],"prefix":"10.1111","volume":"28","author":[{"given":"Can Veysel","family":"\u015eoro\u011flu","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology Ac\u0131badem Mehmet Ali Ayd\u0131nlar University, Institute of Health Sciences  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-705X","authenticated-orcid":false,"given":"Ezgi Gizem","family":"Berkay","sequence":"additional","affiliation":[{"name":"Department of Basic 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